Safety profile and adverse drug reactions with causality assessment of Ticagrelor in Myocardial Infraction

  • S. P. Santhosh Kumar Vivekanandha Medical Care Hospital, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.
  • Shangavi V Assistant Professor
  • Abisha R. S. Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.
  • Aiswaria M. S. Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.
  • Abburi Lalitha Nandini Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.
  • Abitha Aravindakshan Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.
  • Amritha Harish N Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.
Keywords: Dyspnoea, Ticagrelor, Antiplatelet, Acute Coronary Syndrome

Abstract

Introduction: Antiplatelet medications are the most commonly used first-line therapy in acute coronary syndrome (ACS), particularly those undergoing percutaneous coronary intervention (PCI).P2Y12 is one of the two platelet receptors for adenosine diphosphate (ADP), which play a very important role in platelet function and thrombus formation.

Method: In this article, we present 2 case reports of patients, showing severe symptoms of dyspnoea. Then we describe possible mechanisms of these complications when switching Ticagrelor to other antiplatelet drugs, and also make therapeutic recommendations for Ticagrelor-associated therapy based on what we know presently to deal with such symptoms.

Results: In ACS patients, with existing respiratory disorders, Dyspnoea can be fatal. Clinical studies have shown that reduced lung function or low EF is not harmful contraindications for Ticagrelor.

Discussion: However, these groups of patients should be monitored closely after administration of Ticagrelor.

Author Biographies

S. P. Santhosh Kumar , Vivekanandha Medical Care Hospital, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.

Department of Cardiology,

Abisha R. S., Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.

Pharm-D Intern.

Aiswaria M. S., Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.

Pharm-D Intern.

Abburi Lalitha Nandini, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.

Pharm-D Intern.

Abitha Aravindakshan, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.

Pharm-D Intern.

Amritha Harish N, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Namakkal (DT), Tamil Nadu.

Pharm-D Intern.

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Published
2022-06-01
How to Cite
1.
Kumar SPS, V S, R. S. A, M. S. A, Nandini AL, Aravindakshan A, N AH. Safety profile and adverse drug reactions with causality assessment of Ticagrelor in Myocardial Infraction. jpadr [Internet]. 2022Jun.1 [cited 2022Jul.4];3(2):41-5. Available from: https://jpadr.com/index.php/jpadr/article/view/72