Journal of Pharmacovigilance and Drug Research

“Tofersen - A Ray of Hope for ALS Patients” : A Mini Review

HARA PRASAD MISHRA — Thu, 01 Jun 2023 00:00:00 +0000

Despite thorough investigation, amyotrophic lateral sclerosis (ALS) continues to be a
degenerative neurological condition that is inevitably fatal and progresses over time. The limited
understanding of the fundamental causes of ALS has posed challenges in addressing the initial
biological processes of the disease, resulting in therapeutic interventions typically being applied
at later stages of the illness.
The existence of genetic variants in ALS presents a distinctive chance for advancing therapeutic
approaches, as studying genetic associations could unveil valuable information about the causes
of the disease. In the case of genetic ALS, there is a possibility to explore early intervention by
identifying individuals who are at risk and have not yet shown symptoms but possess specific
genetic variations that contribute to the condition. Tofersen, an oligonucleotide, has been
specifically created to diminish the production of superoxide dismutase 1 (SOD1) protein by
breaking down SOD1 mRNA.

Review on Pharmacovigilance perspective of the Pharmacopoeia’s and Formulary of Unani Medicine

Mohd Aleemuddin Quamri , Rabia Malik, Abdul Wadud — Thu, 01 Jun 2023 00:00:00 +0000

The aim of this review is to conceal the pharmacovigilance perspective of certain drugs of fourth degree potency, and substitutes in the preparation of formulations. Such drugs are dealt according to the standard procedures to make use of them, and use of appropriate substitutes in case of non-available drugs. Unani pharmacopeias and formularies have some drugs and dosage forms of concern with reference to pharmacovigilance

Comparison of Pharmacovigilance and Herbovigilance Regulatory Guidelines at the Global level

Kumari Arpana Kajal — Thu, 01 Jun 2023 00:00:00 +0000

Pharmacovigilance is the most cutting-edge technology in the medical field, the most advanced technologies in the medical field. It focuses on identifying, evaluating, analyzing, and preventing pharmacological side effects based on identification evaluation analysis and prevention of pharmacological side effects based on long-term and short-term drug exposure. Through the monitoring of drug safety, pharmacovigilance science seeks to enhance patient safety and population welfare.

Every nation has regulatory organizations examining case reporting data and examines case reporting data and actual drug-related toxicological concerns. All adverse international unfavourable events in the country are centred at Uppsala Monitoring Centre (UMC). UMC determines judgments based on their investigation connected to numerous aspects of every case report, from Herbovigilance to the Pharmacovigilance drug program. The World Health Organization (WHO) was assisted by UMC when making worldwide decision-making on a global scale.

Essential Oil Components of Lemon grass leaves (Cymbopogon citratus) and its importance: A Narrative Review

Thu, 01 Jun 2023 00:00:00 +0000

Cymbopogon citratus, sometimes known as lemongrass, belongs to the Poaceae family. It is a medicinal plant that contains chemicals that can inhibit the growth of pathogens and boost the body's natural defenses against infectious disorders. Lemongrass is frequently used in baked goods, confections, herbal teas, and other non-alcoholic beverages. Lemongrass essential oil is frequently used as a scent in perfumes and beauty products like creams and soaps. The creation of beta carotene, and other nutrients is derived from citral, which is present in high concentrations in lemongrass essential oil. Lemon grass oil is therefore used in several pharmaceutical businesses for its anti-depressant, analgesic, antipyretic, bactericidal, and antiseptic properties due to the presence of diverse chemical elements.

Evaluation of statin utilisation in tertiary care teaching hospital: An observational prospective study, YSR Kadapa

Thu, 01 Jun 2023 00:00:00 +0000

ABSTRACT

Introduction: Statins are highly preferred drugs in the treatment and prevention of atherosclerotic diseases. Statins usage increased in the last two decades. DUE is a cyclic quality-enhancing procedure in the prescription of drugs.

Methods: Our study engaged in compiling various prescribing conditions for statins, assessing their effectiveness and safety, and comparing the lipid profile images of atorvastatin and rosuvastatin. A prospective observational study with the involvement of 150 volunteers The complete data collected is analysed using SAS and Microsoft Excel software. Statistical methods of mean, standard deviation, clinical significance, and Z value are calculated.

Results: Atorvastatin (20 mg, 40 mg, and 80 mg) and Rosuvastatin (5 mg and 10mg) are widely used in the primary, secondary, and tertiary prevention of atherosclerotic cardiovascular and cerebrovascular problems. Average reduction of LDL and total cholesterol levels to 106.5(SD ±11.04) and 203.53 (SD±94) respectively.

Conclusion: Both drugs are equally effective in reducing cholesterol levels. adverse drug reactions observed on long-term usage of 2 to 6 years in 7.33% of volunteers Secondary and tertiary occurrences of CVA are observed due to non-adherence.

Key words: Atorvastatin, cardiovascular and cerebrovascular problems, non

adherence, Re-occurrence, Rosuvastatin.