Ofloxacin/ tinidazole induced fixed drug eruption- a case report

Case Report

Keywords: Ofloxacin, antibiotic, Adverse drug reaction, stomach flu, allergic reaction, Irrational therapy, Tinidazole

Abstract

An immunological cutaneous adverse drug reaction is distinguished as sharply defined lesions with red rashes and sharp border, erythematous lesions with or without blisters developing within an hour or in few cases within a week after drug administration is termed as fixed drug eruptions (FDE). FDE is one of the major forms of drug-induced dermatosis. Various class of drugs that are causative agents for FDE includes antibiotics, anticonvulsants, antivirals, and Non-steroidal anti-inflammatory drugs (NSAID). FDE is easily recognized and differentiated from other drug eruptions since it does not occur voluntarily or during infection. This case report is to spotlight the case of a 52-year-old male patient who was undergoing treatment for acute gastroenteritis and suffered from FDE due to administration of IV Ofloxacin.

Author Biography

Monika Kapoor, I.S.F College of Pharmacy, Moga, Punjab, India

Department of Pharmacy Practice

References

Baltaci D, Akyazi H, Kandis H, Saritas A, Mungan S, Kara IH. Ornidazole-induced fixed drug eruption: A case report. Slovenian Medical Journal, 2012;81(4):337-340.
Bhusan H. The Unseen Story of Tinidazole: Alarm to the Drug Regulatory Bodies. MOJ Clinical & Medical Case Reports, 2015;2(1):3-4.
Dhar S, Sharma VK. Fixed drug eruption due to ciprofloxacin. British Journal of Dermatology, 1996; 134(1), 156-158.
Gautam CS, Aditya S. Irrational drug combinations: need to sensitize undergraduates. Indian journal of pharmacology, 2006;38(3), 169-170.
Gohel KH, Shah KV, Patel S, Joseph JJ, Mathew J. Ofloxacin-induced fixed drug eruptions. Journal of Integrated Health Science, 2020; 8(1): 22-24.
Jain SP, Jain PA. Bullous fixed drug eruption to ciprofloxacin: a case report. Journal of Clinical and Diagnostic Research, 2013;7(4): 744-745.
Jhaj R, Chaudhary D, Asati D, Sadasivam B. Fixed-drug eruptions: What can we learn from a case series. Indian journal of dermatology, 2018; 63(4): 332-337.
Kameswari PD, Selvaraj N, Adhimoolam M. Fixed drug eruptions caused by cross-reactive quinolones. Journal of basic and clinical pharmacy, 2014;5(2): 54-55.
Kumar SM, Mishra R, Pandya P, Bansal A, Singh Bajhaiya B, Mithun M. Tinidazole-Induced Fixed Drug Eruption: A Case Report. International Journal of Medical Research and Review, 2015; 3(7): 777-80.
Patel TK, Thakkar SH, Sharma DC. Cutaneous adverse drug reactions in Indian population: A systematic review. Indian dermatology online journal, 2014; 5(S2):76-86.
Ramani YR, Mishra SK, Rath B, Rath SS. Ofloxacin induced cutaneous reactions in children. Journal of clinical and diagnostic research, 2015; 9(6): FD01- FD02.
Ramineni HB, Eluri P, Vipparla K, Suryadevara V. Ofloxacin induced hypersensitivity reaction. International Journal of Research in Medical Sciences, 2015; 3(1): 349-351.
Marrapu SP, Sanaka M, Ali SF, Shafiya S, Raghu RV, Rao NR. Ofloxacin induced multiple fixed drug eruptions- A Case report. International Journal of Research in Pharmacology & Pharmacotherapeutics, 2014; 3(3):169-172.
Published
2021-06-06
How to Cite
1.
Monika Kapoor. Ofloxacin/ tinidazole induced fixed drug eruption- a case report. jpadr [Internet]. 2021Jun.6 [cited 2021Oct.16];2(1):20-2. Available from: https://jpadr.com/index.php/jpadr/article/view/22