A Case Report on Tolperisone Induced Anaphylactic Reaction

Abstract

Introduction: Tolperisone is a centrally acting muscle relaxant commonly used to treat muscle spasticity and pain associated with neurological and orthopedic conditions. While generally well tolerated, rare hypersensitivity reactions, including anaphylaxis, have been documented.

Case Presentation: This case report presents a 54-year-old female with a medical history of hypertension and type 2 diabetes mellitus, who developed generalized weakness, malaise and difficulty performing daily tasks within an hour of taking tolperisone. The patient had experienced a similar episode three weeks prior but did not seek medical attention. After taking another dose of tolperisone, the patient experienced worsening symptoms, including weakness following multiple episodes of loose stools, leading to hospitalization. Laboratory investigations revealed elevated white blood cell count and high blood glucose levels. the diagnosis of anaphylaxis secondary to tolperisone was confirmed, and the patient was treated accordingly. Although tolperisone is known to cause mild side effects like dizziness, fatigue, and gastrointestinal disturbances, severe allergic reactions such as anaphylaxis are rare.

Conclusion: A few cases have been reported in the literature, emphasizing the need for caution in patients with a history of allergies. This case underscores the importance of recognizing and managing hypersensitivity reactions promptly to prevent serious complications and ensure positive patient outcomes.