Lymphoproliferative skin lesion as a previously unreported adverse event detected in a patient receiving mSTR TB treatment

  • Hakob Atshemyan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,
  • Naira Khachatryan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,
  • Artak Manukyan National Center for Pulmonology, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204
  • Anush Khachatryan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204
  • Alvard Poghosyan Haematology Center after prof. R. Yeolyan MoH RA, Armenia, Yerevan, H Nersisyan str. 7, PIN code: 0014,
Keywords: adverse event, lymphoproliferative skin lesion, rifampicin resistant tuberculosis, mSTR treatment

Abstract

Case Presentation: This case report presents an unreported adverse event detected when conducting pharmacovigilance activity among the patients’ cohort receiving short, modified, all-oral treatment regimens (mSTR) for rifampicin-resistant tuberculosis (TB). Lymphoproliferative skin lesion was diagnosed histologically.

Results: The withdrawal clinical response and re-challenge positive test were detected, and the causal relationship was defined as “probable”.

 

Author Biographies

Hakob Atshemyan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,

mSTR Study Doctor,

Naira Khachatryan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,

Deputy Director for Tuberculosis Control Programs,

Artak Manukyan, National Center for Pulmonology, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204

Director of the National Center for Pulmonology.

Anush Khachatryan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204

Head of Data Management and Monitoring.

Alvard Poghosyan, Haematology Center after prof. R. Yeolyan MoH RA, Armenia, Yerevan, H Nersisyan str. 7, PIN code: 0014,

Pathologist.

References

Margo, C. M., Crowson. A. N. (1996). Drug-induced immune dysregulation as a cause of atypical cutaneous lymphoid infiltrates: A hypothesis. Human Pathology, 27(2), 125-132.

Novice, T., Ahn, J. W., Wilcox, R., Tejasvi, T., Hristov, A., & Mancuso, J. (2020). Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma. JAAD case reports, 6(4), 311–315.

WHO. 2013. The use of the WHO-UMC system for standardised case causality assessment. WHO Publications, 1-3. Retrieved from: https://www.who.int/publications/m/item/WHO-causality-assessment

Published
2022-06-01
How to Cite
1.
Atshemyan H, Khachatryan N, Manukyan A, Khachatryan A, Poghosyan A. Lymphoproliferative skin lesion as a previously unreported adverse event detected in a patient receiving mSTR TB treatment. jpadr [Internet]. 2022Jun.1 [cited 2022Jul.4];3(2):34-7. Available from: https://jpadr.com/index.php/jpadr/article/view/77