Exploring position of colchicine in management of COVID 19 – A systematic review

  • Shambo Samrat Samajdar School of Tropical Medicine
  • Shrestha Dutta Department of Biotechnology, Amity University Kolkata
  • Aneek Ghosh Rabindranath Tagore International Institute of Cardiac Sciences, Mukundapur, Kolkata
  • Shatavisa Mukherjee School of Tropical Medicine, Kolkata
  • Jayanta Sharma Apollo Multi-speciality Hospital,Kolkata
  • Anwesha Behera Department of Biotechnology, Amity University Kolkata
  • Oyendrilla Mitra Department of Biotechnology, Amity University Kolkata
  • Ishanee Das Sharma Department of Biotechnology, Amity University Kolkata
  • Mohojit Chakraborty Pharmacist, Independent Clinical Research Coordinator, Kolkata
  • Santanu K Tripathi School of Tropical Medicine, Kolkata
Keywords: Colchicine, SARS CoV2, Inflammatory Response

Abstract

Introduction: One of the goals of managing COVID 19 patients is controlling inflammatory responses, which are majorly responsible for morbidity and mortality associated with SARS CoV 2 infection. A novel approach to address inflammation could be Colchicine. It invariably decreases pulmonary complexities, showing antimitotic action, causing metaphase arrest by inhibiting microtubule and spindle formation, and is effective in reducing granulocyte migration, ultimately reducing inflammation.

Method: For this systemic review, literature was searched using PubMed, Embase, Cochrane Central, medRxiv, and researchsquare.com. The keywords used were – COVID 19, colchicine, SARS-CoV-2, and clinical outcome. Studies published between January 2020 and October 2021 were evaluated and screened to identify those that had reported the effect of colchicine in SARS CoV 2 infected patients and to assess clinical outcomes including mortality, intensive care unit (ICU) admissions, or mechanical ventilation.

Results and Discussion: In this systematic review among 8 quantitative clinical researchers, it was observed that colchicine administration was related to improved clinical outcomes in COVID 19 patients, without statistical significance.

Conclusion: The mortality risk of COVID-19 patients can be reduced by colchicine. Need more prospective clinical researches which could help to evaluate the efficacy of colchicine to treat COVID-19 patients in different stages of the disease, including post-hospitalization and long-term care follow-up.

Author Biographies

Aneek Ghosh, Rabindranath Tagore International Institute of Cardiac Sciences, Mukundapur, Kolkata

Resident Medical Officer, Critical Care Medicine.

Shatavisa Mukherjee, School of Tropical Medicine, Kolkata

PhD Scholar (Pharmacology), Department of Clinical & Experimental Pharmacology,

Jayanta Sharma, Apollo Multi-speciality Hospital,Kolkata

Senior Consultant, Internal Medicine and Critical Care.

Santanu K Tripathi, School of Tropical Medicine, Kolkata

Formerly Head, Department of Clinical & Experimental Pharmacology.

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Published
2022-06-01
How to Cite
1.
Shambo Samrat Samajdar, Dutta S, Ghosh A, Mukherjee S, Sharma J, Behera A, Mitra O, Das Sharma I, Chakraborty M, Tripathi SK. Exploring position of colchicine in management of COVID 19 – A systematic review. jpadr [Internet]. 2022Jun.1 [cited 2022Nov.26];3(2):16-1. Available from: https://jpadr.com/index.php/jpadr/article/view/73