Cerebral venous sinus thrombosis associated with thrombocytopenia after the second dose of Chadox1 nCov-19 vaccination

Case Study

  • Sagar R. Bhimani Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
  • Harsha D. Makwana L.G AMC MET Medical College, Ahmedabad, Gujarat, India
  • Supriya D. Malhotra Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
Keywords: SARS-CoV-2, Covid-19 Vaccine, Cerebral Venous Sinus Thrombosis, Vaccine-induced Immune Thrombotic Thrombocytopenia, Adverse Event following Immunization.


Introduction: Reports of cerebral venous sinus thrombosis (CVST) after vaccination against SARS-CoV-2 have raised safety concerns and an emerging mechanism termed vaccine-induced immune thrombotic thrombocytopenia (VITT) was identified.

Objective: We aimed to estimate the frequency of CVST and other cerebrovascular events after vaccination.

Case study: We describe the case of a young male, who developed severe thrombocytopenia and CVST following the second dose of the covid 19 vaccine. He presented with a headache, with subsequent rapid neurological deterioration. The patient was successfully treated and discharged with the stable condition after 09 days of admission. We attribute this Adverse Event following Immunization (AEFI) of thrombotic condition to the vaccine due to the remarkable temporal relationship.

Conclusions: The proposed mechanism of VITT is the production of rogue antibodies against platelet factor-4 resulting in massive platelet aggregation. Radiologists and physicians should be aware and pay attention to early imaging signs of cerebral venous sinus thrombosis for timely diagnosis and treatment.


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Author Biographies

Sagar R. Bhimani, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India

Resident Doctor, Department of Pharmacology

Harsha D. Makwana, L.G AMC MET Medical College, Ahmedabad, Gujarat, India

Professor, Department of Emergency Medicine

Supriya D. Malhotra, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India

Professor and Head, Department of Pharmacology


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How to Cite
Bhimani S, Makwana H, Malhotra S. Cerebral venous sinus thrombosis associated with thrombocytopenia after the second dose of Chadox1 nCov-19 vaccination. jpadr [Internet]. 2021Dec.1 [cited 2023Jun.4];2(4):32-5. Available from: https://jpadr.com/index.php/jpadr/article/view/53