A rare case of accelerated gingival overgrowth with high dose amlodipine therapy
Gingival overgrowth represents an over-exuberant response to a variety of local and systemic conditions. Certain anticonvulsants, immunosuppressive drugs, and a number of calcium channel blockers have been shown to produce similar gingival overgrowth in susceptible patients. Among the calcium channel blockers, nifedipine is most frequently associated with gingival overgrowth. Whereas, there is limited evidence of amlodipine-induced gingival hyperplasia. We report a case of accelerated drug-induced gingival overgrowth in a 60-year-old hypertensive patient taking amlodipine at a dose of 10 mg.
Nyska A, Shemesh M, Tal H, Dayan D. Gingival hyperplasia induced by calcium channel blockers: mode of action. Medical Hypotheses, 1994;43(2):115- 118.
Bhatia V, Mittal A, Parida AK, Talwar R, Kaul U. Amlodipine induced gingival hyperplasia: a rare entity. International journal of cardiology, 2007;122(3):e23- e24.
Dougall HT, McLay J. A comparative review of the adverse effects of calcium antagonists. Drug safety, 1996;15(2):91-106.
Ellis JS, Seymour RA, Thomason JM, Monkman SC, Idle JR. Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth. Lancet. 1993;341(8852):1102-1103.
Fares H, DiNicolantonio JJ, O'Keefe JH, Lavie CJ. Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes. Open Heart, 2016;3(2):e000473.
Livada R, Shiloah J. Calcium channel blocker-induced gingival enlargement. Journal of human hypertension, 2014;28(1):10-14.
Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. Journal of periodontology, 1997;68(7):676-678.
Mavrogiannis M, Ellis JS, Thomason JM, Seymour RA. The management of drug-induced gingival overgrowth. Journal of clinical periodontology, 2006;33(6):434-439.
Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clinical pharmacology and therapeutics, 1981;30(2):239-245.
Nery EB, Edson RG, Lee KK, Pruthi VK, Watson J. Prevalence of nifedipine-induced gingival hyperplasia. Journal of periodontology, 1995;66(7):572-578.
Raman PG, Mishra VN, Singh D. Nifedipine induced gingival hyperplasia. The Journal of the Association of Physicians of India, 1988;36(3):231-233.
Seymour RA, Thomason JM, and Ellis JS. The pathogenesis of drug-induced gingival overgrowth. Journal of Clinical Periodontology, 1996;23(3):165-175.
Seymour RA. Calcium channel blockers and gingival overgrowth. British dental journal, 1991;170(10):376- 379.
Marshall RI, Bartold PM. A clinical review of drug-induced gingival overgrowths. Australian dental journal, 1999;44(4):219-232.
Triveni MG, Rudrakshi C, Mehta DS. Amlodipine-induced gingival overgrowth. Journal of Indian Society of Periodontology, 2009;13(3):160-163.
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