Vitamin K1 injection induced localized scleroderma like lesion in pregnancy: A case report

  • Priyanka Banik R.  G.  Kar  Medical and  Hospital,  Kolkata,  West  Bengal,  India
  • Lopamudra Dhar Chowdury R. G. Kar Medical and Hospital, Kolkata, West Bengal, India
  • Koustuv Chowdhury R. G. Kar Medical and Hospital, Kolkata, West  Bengal, India
  • Abhik Saha Indian Pharmacopoeia Commission,National Coordination Centre, Pharmacovigilance Progmamme of India
Keywords: Adverse Drug Reaction, Phytomenadione, Naranjo scale, Modified-Hartwig’s-criteria

Abstract

Cutaneous reaction due to Vitamin K1 (Phytomenadione) injection can present as hypersensitivity reaction at the injection site with morphea like lesion that can be deep  seated, involving the dermis & subcutaneous tissue, several days or weeks after  injection of vitamin K1. Texier  Disease,which is a scleroderma like lesion secondary to  vitamin K1 injection is one of the rarely encountered & reported condition.

Localised scleroderma is a rare autoimmune disorder characterized by fibrosis of the  skin and subcutaneous tissues. Although its etiology is not fully understood, several  factors including environmental triggers and genetic predisposition have been   implicated.

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Author Biographies

Priyanka Banik, R.  G.  Kar  Medical and  Hospital,  Kolkata,  West  Bengal,  India

2nd  year  MD  Post  Graduate  Trainee,  Department  of  Pharmacology

Lopamudra Dhar Chowdury, R. G. Kar Medical and Hospital, Kolkata, West Bengal, India

Professor, Department of Pharmacology

Koustuv Chowdhury, R. G. Kar Medical and Hospital, Kolkata, West  Bengal, India

Assistant Professor, Department of  Pharmacology

Abhik Saha, Indian Pharmacopoeia Commission,National Coordination Centre, Pharmacovigilance Progmamme of India
Jr. Pharmacovigilance Associate Indian Pharmacopoeia Commission National Coordination Centre  Pharmacovigilance Progmamme of India R G Kar Medical College

References

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SFDA PRC (2011) Alert regarding serious allergic reactions to vitamin K1 injection. National Center for ADR Monitoring

Sousa, T., Hunter, L., Petitt, M., & Wilkerson, M. G. (2010). Letter: Localized cutaneous reaction to intramuscular vitamin K in a patient with acute fatty liver of pregnancy. Dermatology online journal, 16(12), 16.

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Published
2024-06-01
How to Cite
1.
Banik P, Dhar Chowdury L, Chowdhury K, Saha A. Vitamin K1 injection induced localized scleroderma like lesion in pregnancy: A case report. jpadr [Internet]. 2024Jun.1 [cited 2024Oct.14];5(2):13-5. Available from: https://jpadr.com/index.php/jpadr/article/view/172