CASE REPORT:  Levetiracetam Induced Acute Pancreatitis– An ADR Case Report:

Dr Shiva Murthy Nanjundappa; Anjali  Venkat; Rohit  Krishnappa

Shiva Murthy N Professor, Department of Pharmacology, Dr Chandramma Dayananda Sagar Institute of Medical Education and Research (CDSIMER), Devarakaggalahalli, Harohalli, Ramanagara District, Karnataka, India
Anjali Venkat Dr Chandramma Dayananda Sagar Institute of Medical Education and Research (CDSIMER), Dayanand Sagar University, Devarakaggalahalli, Harohalli, Ramanagara District, Karnataka, India.
Rohit Krishnappa Dr Chandramma Dayananda Sagar Institute of Medical Education and Research (CDSIMER), Dayanand Sagar University, Devarakaggalahalli, Harohalli, Ramanagara District, Karnataka, India.

Keywords: Levetiracetam, Acute Pancreatitis, Pharmacovigilance, Adverse Drug Reaction

Abstract

Introduction: Acute pancreatitis is an acute inflammation of the pancreas due to premature activation of pancreatic pro-enzymes, resulting in various degrees of damage. There are various causes of acute pancreatitis, including alcohol poisoning, infections, etc. One of the rarer known causes of acute pancreatitis is an adverse drug reaction due to the anti-epileptic drug levetiracetam.

Case report: A 35-year-old male patient presented to the casualty with complaints of sudden-onset pain in the abdomen that was progressive in intensity, nausea, and vomiting for 1 day. He has been an alcoholic for over 20 years. He has had a similar history—on and off since 3 years—and has been on Tab. Levetiracetam (500mg) for epilepsy for two years. Initial examination revealed a soft abdomen with tenderness in the epigastric region. In this patient, investigations revealed serum amylase of 542 IU/L (the normal reference range is 28–100 IU/L). Raised more than 5 times the normal reference range, and abdominal pain was consistent with pancreatitis.

Conclusion: In this article, we discussed various possible causes of acute pancreatitis, with a special focus on levetiracetam induced acute pancreatitis. Further studies are required to understand the etiological factors, epidemiological factors, and outcome of treatment.

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Author Biographies

Shiva Murthy N, Professor, Department of Pharmacology, Dr Chandramma Dayananda Sagar Institute of Medical Education and Research (CDSIMER), Devarakaggalahalli, Harohalli, Ramanagara District, Karnataka, India

Dr. Shiva Murthy N MBBS, MD, MBA.,

Professor, Dept of Pharmacology, CDSIMER

Founder president, Medical Pharmacologists Society® (2016),
22+ yrs experience (13 yrs industry and 09 yrs medical college), PV coordinator, AMC,
Managing Editor - JPADR journal, Reviewer, IJP Journal,
Animal ethics committee/Safety committee member, SLS company etc
Awards/Important achievements:
First rank (MD pharmacology 2001, RGUHS),
Awarded 1st prize (2021) and 2nd prize (2022) for PV related short movies at NCC-IPC (PVPI) organized NPW events, MOHFW, Govt of India,
Awarded 2nd prize (2021 and 2023) for oral scientific paper presentation at Hyperpiesia conference held at SBMC, Chennai, and KSMPCON 2023 held at SSMCRC, Tumkur.
His projects received Research Society Merit Certificate (2003) at St John's medical college, and 3rd prize for the oral presentation (2003) at SRC-IPS Conference,
He is an Awardee of “INSC Research Excellence Award - 2023” for his publication on topic NSAIDS & its SARs for building safer products.
Published 5 books (“Pharmacovigilance Reflective Writing E-Book”, “Clinical Trial management”, “Aarogya Janapada”, “Molehalu: Navajaatha Shishuvina Amrutha” and “CDSIMER’s Pharmacology Record Book – Vol 1 and Vol 2”.
Published 17 articles in peer reviewed journals, 20 papers in conference. 2 patents to his credit,
Organized more than 35 scientific events (Workshops, seminars, Webinars, Conferences). Speaker in Various national and international conferences,
Pharmacovigilance Reflective Writing E-Book - featured in Uppsala reports (an official publication of UMC, Sweden, WHO).
Advisory board member for Clinical Trial Magnifier (CTM), online journal by CT Center, University of Hong Kong, and Board member of World Wide CR leaders forum.

Anjali Venkat, Dr Chandramma Dayananda Sagar Institute of Medical Education and Research (CDSIMER), Dayanand Sagar University, Devarakaggalahalli, Harohalli, Ramanagara District, Karnataka, India.

Student, MBBS, 3rd Year

Rohit Krishnappa, Dr Chandramma Dayananda Sagar Institute of Medical Education and Research (CDSIMER), Dayanand Sagar University, Devarakaggalahalli, Harohalli, Ramanagara District, Karnataka, India.

Professor, General Surgery Department

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CASE REPORT: Levetiracetam Induced Acute Pancreatitis– An ADR Case Report

Levetiracetam Induced Pancreatitis

Abstract

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