Drug related problems on anti-platelets and anti-coagulants in stroke
Abstract
Introduction: Antiplatelet agents prevent platelets from dumping and prevent clots from forming and growing. Anticoagulants slow down clotting thereby reducing fibrin formation and preventing clots. Drug-related problems are a major concern in the view of physical, psychological, and economic burden to patients.
Objectives: The aim of the research work is to access, evaluate and monitor the drug-related problems on antiplatelet and anticoagulants in stroke patients.
Methods: In this study 300 numbers of patients were screened including both males and females of all age groups in a super specialty hospital.
Results: The number of ADRs was found to be predominantly associated with a male as compared to females as well as most ADRs were reported for patients with cardiac stroke as compared to ischemic stroke and hemorrhagic stroke.
Conclusions: Low molecular weight heparins, aspirin, clopidogrel drugs resulted in various adverse drug reactions. Mostly 114 cases of ADR were due to drug-drug interactions followed by drug-food interactions and drug ethanol interactions as was concluded from the study.
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Alvarez-Sabín, J., Ortega, G., Jacas, C., Santamarina, E., Maisterra, O., Ribo, M., Molina, C., Quintana, M., & Román, G. C. (2013). Long-term treatment with citicoline may improve poststroke vascular cognitive impairment. Cerebrovascular diseases (Basel, Switzerland), 35(2), 146–154.
Dahal, P., Kumar, S. B., Venkataram, R., Fuloria, P. C. (2013). Assesment of clinical pharmacist intervention in tertiary are treating hospital of southern India. Asian journal of pharmaceutical and clinical research, 6(2), 258-261.
DeGregorio-Rocasolano, N., Martí-Sistac, O., Ponce, J., Castelló-Ruiz, M., Millán, M., Guirao, V., García-Yébenes, I., Salom, J. B., Ramos-Cabrer, P., Alborch, E., Lizasoain, I., Castillo, J., Dávalos, A., & Gasull, T. (2018). Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage. Redox biology, 15, 143–158.
European Stroke Organisation (ESO) Executive Committee, & ESO Writing Committee (2008). Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovascular diseases (Basel, Switzerland), 25(5), 457–507.
Flesch, M., & Erdmann, E. (2006). The problem of polypharmacy in heart failure. Current cardiology reports, 8(3), 217–225.
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Jr, Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., Murray, K. T., Sacco, R. L., Stevenson, W. G., Tchou, P. J., Tracy, C. M., Yancy, C. W., & ACC/AHA Task Force Members (2014). 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation, 130(23), 2071–2104.
Jauch, E. C., Saver, J. L., Adams, H. P., Jr, Bruno, A., Connors, J. J., Demaerschalk, B. M., Khatri, P., McMullan, P. W., Jr, Qureshi, A. I., Rosenfield, K., Scott, P. A., Summers, D. R., Wang, D. Z., Wintermark, M., Yonas, H., American Heart Association Stroke Council, Council on Cardiovascular Nursing, Council on Peripheral Vascular Disease, & Council on Clinical Cardiology (2013). Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 44(3), 870–947.
Saver J. L. (2008). Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. Reviews in neurological diseases, 5(4), 167–177.
Sobrino, T., Rodríguez-González, R., Blanco, M., Brea, D., Pérez-Mato, M., Rodríguez-Yáñez, M., Leira, R., & Castillo, J. (2011). CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke. Neurological research, 33(6), 572–577.
Steinberg, B. A., Peterson, E. D., Kim, S., Thomas, L., Gersh, B. J., Fonarow, G. C., Kowey, P. R., Mahaffey, K. W., Sherwood, M. W., Chang, P., Piccini, J. P., Ansell, J., & Outcomes Registry for Better Informed Treatment of Atrial Fibrillation Investigators and Patients (2015). Use and outcomes associated with bridging during anticoagulation interruptions in patients with atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). Circulation, 131(5), 488–494.
Viktil, K. K., & Blix, H. S. (2008). The impact of clinical pharmacists on drug-related problems and clinical outcomes. Basic & clinical pharmacology & toxicology, 102(3), 275–280.
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