Anti-viral activity of Withania somnifera phytoconstituents against corona virus (SARS-COV-2)
Abstract
Introduction: Traditional medicine practitioners use natural active compounds found in medicinal plants to treat a variety of diseases. Withania somnifera, also known as Ashwagandha, Winter Cherry, and Indian Ginseng, is one such herb that has been used to cure a variety of ailments since the time of Ayurveda, India's ancient medical system. The Solanaceae family includes Withania somnifera.
Method: The exhaustive literature survey has been done via various search engines, review articles, research articles, google scholar, PubMed, internet. According to recent investigations, Withanolides, a bioactive ingredient of Withania somnifera, have shown therapeutic efficacy in decreasing the intensity of SARS-CoV-2 and in providing medical care and attention to individuals suffering from COVID-19. Free-radical scavenging is another feature of Ashwagandha. This review article contains information regarding phytochemistry and antiviral activity against coronavirus.
Results: In-silico investigations have revealed that it has a high binding affinity for the ACE2–RBD interface, which could prevent SARS COV 2 from infecting cells. In India, ashwagandha is available as a liquid, tablet, or powder. This review article's aim is to provide all the information and research work that should be done by researchers recently against SARS COVID-19.
Discussion: Due to its immune-modulatory, anti-stress, and antiviral characteristics, Ashwagandha has been chosen. The aim of the review article is to review ‘the anti-viral activity of Withania somnifera phytoconstituents against coronavirus (SARS-COV-2).
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