Diethylene Glycol Poisoning – Past to Present
Abstract
Probably we all have heard many depressing stories already about deadly cough syrup adulterated with Diethylene Glycol (DEG). DEG is a very infamous and dangerous chemical used for mostly preparing pharmaceutical products and consumer products. DEG makes it an excellent counterfeit for pharmaceutical-grade glycerine or propylene glycol, it has a sweetish taste which makes DEG suitable for pharmaceutical preparations. it had been in news for a long back from The Massengill Incident to the recent Gambia tragic incident. The hallmark of DEG poisoning is Acute Renal Failure (ARF). Over the years, DEG has been loaded into all varieties of medicine such as cough syrup, fever medication, injectable drugs, etc. although the batch of the adulterated medicines was recalled after the alert by the time it was recalled it has already caused damage hence, it's not allowed to use in food and drugs by many Health authorities. WHO had warned on time to Health Authorities regarding DEG Mass poisoning. Despite so many tragic incidents and deaths in multiple countries, there is still a lack of regulation for using DEG for pharmaceutical preparations. The generation of scientific knowledge and strict regulation required worldwide to control mass poisoning so that medicines can benefit humankind greatly instead of harming them.
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References
Barnagarwala, T. (2022). Mumbai’s JJ Hospital to The Gambia: 36 years apart but a familiar story of deadly toxic drugs. Scroll. In. Retrieved from: https://scroll.in/article/1036860/mumbais-jj-hospital-to-the-gambia-36-years-apart-but-a-familiar-story-of-deadly-toxic-drugs
Bogdanich W, Hooker J, Health: A Toxic Pipeline. (2007). The New York Times. Retrieved from: https://rjionline.org/rji/wp-content/uploads/sites/2/2020/11/nyt_toxic_pipeline.pdf
Bowie, & McKenzie D. (1972). Diethylene glycol poisoning in children. South African Medical Journal, 46(27), 931–934.
Casco, J. (2015). Wine, Lies and Glycol - The Austrian Antifreeze Scandal. The Wine Stalker. Retrieved from: https://www.thewinestalker.net/2015/04/austria.html
CFR - Code of Federal Regulations Title 21. (n.d.). U.S. Food And Drug Administration. Retrieved November 26, 2022, from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820
Chinese counterfeits prove deadly for Panama. Commercial Crime Services. (2017, July 7). Retrieved from: https://www.icc-ccs.org/index.php/356-chinese-counterfeits-prove-deadly-for-panama
Explainers, F. P. (2022, October 7). Gambia children tragedy: How cough syrups can lead to deaths. Firstpost. Retrieved from: https://www.firstpost.com/explainers/gambia-children-deaths-how-cough-syrups-can-lead-to-fatalities-11401481.html
Fatalities Associated with Ingestion of Diethylene Glycol-Contaminated Glycerin Used to Manufacture Acetaminophen Syrup -- Haiti, November 1995-June 1996. (n.d.). Retrieved from: https://www.cdc.gov/mmwr/preview/mmwrhtml/00043194.htm
Hanif, M., Mobarak, M. R., Ronan, A., Rahman, D., Donovan Jr, J. J., & Bennish, M. L. (1995). Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic. BMJ, 311(6997), 88–91
Kraut, J. A., & Kurtz, I. (2007). Toxic Alcohol Ingestions: Clinical Features, Diagnosis, and Management. Clinical Journal of the American Society of Nephrology, 3(1), 208–225.
Mao, B. F. (2022, October 20). Indonesia bans all syrup medicines after death of 99 children. BBC News. Retrieved from: https://www.bbc.com/news/world-asia-63324653
Marraffa, J. (2014). Diethylene Glycol. Encyclopedia of Toxicology, 140–142.
Marraffa, J. M., Holland, M. G., Stork, C. M., Hoy, C. D., & Hodgman, M. J. (2008). Diethylene Glycol: Widely Used Solvent Presents Serious Poisoning Potential. The Journal of Emergency Medicine, 35(4), 401–406.
Minns, A. (2012, December 21). Diethylene Glycol Poisoning. California Poison Control System (CPCS). Retrieved from: https://calpoison.org/news/diethylene-glycol-poisoning
Okuonghae, H. O., Ighogboja, I. S., Lawson, J. O., & Nwana, E. J. C. (1992b). Diethylene glycol poisoning in Nigerian children. Annals of Tropical Paediatrics, 12(3), 235–238.
Raghavan, P. (2020, March 12). Behind killer cough syrup Coldbest: Glaring gaps in regulation and its manufacture. The Indian Express. Retrieved from: https://indianexpress.com/article/india/behind-killer-cough-syrup-glaring-gaps-in-regulation-and-its-manufacture-6310065/
Sanchez, Z. M., Oliveira, C. L., Laranjeira, R., & Caetano, R. (2020). Intoxication and Deaths from Diethylene Glycol Present in Brazilian Craft Beers. Journal of Studies on Alcohol and Drugs, 81(4), 522–523.
Schep, L. J., Slaughter, R. J., Temple, W. A., & Beasley, D. M. G. (2009). Diethylene glycol poisoning. Clinical Toxicology, 47(6), 525–535.
Schier, J. (2009, December). Fatal Poisoning Among Young Children from Diethylene Glycol-Contaminated Acetaminophen --- Nigeria, 2008--2009. CDC Retrieved from: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5848a2.htm
Scientific Committee on Consumer Products SCCP - OPINION ON Diethylene glycol. (2008, June 24). European Commission. Retrieved from: https://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_139.pdf
The Chemical Company. (2022, March 21). Diethylene Glycol (DEG). The Chemical Company. Retrieved from: https://thechemco.com/chemical/diethylene-glycol/
Thiagarajan, K. (2022). WHO investigates cough syrups after deaths of 66 children in Gambia. BMJ. (379).
Worldwide toothpaste incident. (2007). Health News BD. Retrieved from: https://winksite.com/xhtml/ms_fo_pg_v?susid=30373&fid=21583&id=17628
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